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. 2021 Jul 19;12:4391. doi: 10.1038/s41467-021-24643-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Col2⁺ LEC progenitors in the peritendineum as well as adjacent connective tissues adopt LEC fate in the traumatically injured Achilles tendon at the onset of HO development. Downregulated FGFR3 expression in LECs associated with inflammatory milieu inhibits local lymphatic formation via upregulating BMPR1a signaling, which further increases local inflammatory levels and subsequently aggravates HO pathogenesis.