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. 2021 Jul 6;14:706494. doi: 10.3389/fnmol.2021.706494

Figure 2.

Figure 2

Membrane and firing properties were changed in pyramidal neurons in layer 5 of the mPFC. (A–C) Resting membrane potential (A), input resistance (B), membrane capacitance (C) of pyramidal neurons in layer 5 of mPFC of SIK1-WT or -MT mice. (D–G) threshold (D), half-peak width (E), rise time (F), and decay time (G) of the action potential of the pyramidal neurons in layer 5 of the mPFC. (H) Representative traces of induced action potentials responded to 240 pA injected currents. (I) Graph for the relationship between spike frequency and injected current. Input resistance and spike frequency of action potential were increased, and membrane capacitance and decay time of action potential were decreased in SIK1-MT mice. The numbers of neurons and mice used in each analysis are shown on the bar (neurons/mice) in the graphs. Statistical analysis was made by Student's t-test. Statistical significance was indicated by asterisks (*p < 0.05 and **p < 0.01).