Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 6;14:706494. doi: 10.3389/fnmol.2021.706494

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Badawi, Mori, Kurihara, Yoshizawa, Nohara, Kouyama-Suzuki, Yanagawa, Shirai and Tabuchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Risperidone reduces frequencies of mEPSCs and action potentials in the SIK1-MT mice. (A) Representative traces of mEPSC recorded from pyramidal neurons in layer 5 of the mPFC in saline (Sal)- or risperidone (Ris)-injected SIK1-MT mice. (B) Cumulative distribution of inter-event intervals and the mean values of the frequency of mEPSCs were shown in the graph. The frequency of mEPSCs was decreased in risperidone-injected SIK1-MT mice. (C), Cumulative distribution and the mean values of the amplitude of mEPSCs were shown in the graph. The amplitude of mEPSCs was unchanged between saline- and risperidone-injected SIK1-MT mice. (D) Representative traces of mIPSC recorded from the layer 5 pyramidal neurons in mPFC of saline (Sal)- and risperidone (Ris)-injected SIK1-MT mice were shown. (E) Cumulative distribution of the inter-event intervals and the mean values of the frequency of mIPSCs were shown in the graph. (F) Cumulative distributions and mean values of the amplitude of mIPSCs were shown in the graph. (G) The scatter plot shows the relationship between the frequencies of mIPSC (x-axis) and mEPSC (y-axis). Each dot represents a single neuron from saline- or risperidone-injected SIK1-MT mice. (H) E/I balance index of saline (Sal)- and risperidone (Ris)-injected SIK1-MT mice is shown. E/I balance is unchanged between saline- and risperidone-injected SIK1-MT mice. (I–K) Resting membrane potential (I), input resistance (J), membrane capacitance (K) of pyramidal neurons in layer 5 of mPFC of saline (Sal)- and risperidone (Ris)-injected SIK1-MT mice. (L–N) half-peak width (L), rise time (M), and decay time (N) of the action potential of the pyramidal neurons in layer 5 of the mPFC of saline (Sal)- and risperidone (Ris)-injected SIK1-MT mice. (O) Representative traces of induced action potentials responded to 240 pA injected currents. (P) Graph for the relationship between spike frequency and injected current. Spike frequency of the action potential was decreased in risperidone-injected SIK1-MT mice. The numbers of neurons and mice used in each analysis are shown on the bar (neurons/mice) in the graphs. Statistical analysis was made by Student's t-test. Statistical significance was indicated by asterisks (*p < 0.05).