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. 2021 Jul 19;11:14726. doi: 10.1038/s41598-021-94031-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of Metabolites in heated SKOV3 cells. (A) Log2 fold change of metabolites in SKOV3 cells after hyperthermia, as compared to control SKOV3 cells. Significant change according to a fold change greater than 2 is indicated by colors (red: upregulated, green: downregulated). (B) Enriched metabolic pathways identified for the affected metabolites in SKOV3 after hyperthermia. Green and Red: Predicted as downregulated and upregulated pathways, respectively. (C) Schematic of the glycolysis pathway. Enzymes are underlined. Enzymes and metabolites highlighted in green represent downregulated proteins and metabolites in SKOV3 cells after hyperthermia. (D) Relative amounts of metabolites involved in glycolysis. Average ± S.D.; n = 3. *P < 0.05; ***P < 0.001.