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. 2021 Jul 19;11:14726. doi: 10.1038/s41598-021-94031-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detailed proteomics analysis of heated SKOV3 cells. (A) Venn diagrams of downregulated proteins (left) and upregulated proteins (right) in A2780 and SKOV3 cells after hyperthermia. Data were adapted from Hatakeyama H⁸. (B) Graphs show the top five enriched GO annotations for biological processes for differentially expressed downregulated proteins (upper) and upregulated proteins (lower) in SKOV3 cells. (C) Volcano plots of differentially expressed proteins in A2780 (upper) and SKO3 (lower) cells after hyperthermia. Proteins associated glycolysis and protein ubiquitination were represented as green and red dots. (D) Potential connections between glycolysis-related and ubiquitination-related proteins. Red and green indicate upregulation and downregulation, respectively. The lines indicate binding of two gene products, and lines terminating with arrows indicate one gene product acting on another gene product.