Figure 6.

Monte Carlo simulations to investigate relationship of joint uncertainty in D₀, V_d, k_e, and k_a on model output for the GFAP model. One thousand runs are shown. (A–E) Scatter plots of model output by input and parameter at 5 h. (F–J) Scatter plots of model output by input and parameter at 50 h. Model output (Cp) correlates positively with biomarker release D₀ and negatively with V_d. Uncertainty in estimates of k_a and k_e have a smaller influences on model output. The positive correlation of k_a with C_p is most apparent at 5 h and the negative correlation of k_e with C_p is most apparent at 50 h.