Table 2.
Kinetic models with calculated parameters.
| Biomarker | Parameter | Input | |||
|---|---|---|---|---|---|
| model | ke* | ka* | F† | Nominal D0 | Nominal Vd |
| S100B | 0.462 | 0.5 | 0.8 | 400,000 | 5,000 |
| UCH-L1 | 0.0866 | 0.09 | 0.8 | 400,000 | 5,000 |
| tau | 0.0693 | 0.07 | 0.8 | 400,000 | 5,000 |
| GFAP | 0.0193 | 0.08 | 0.8 | 400,000 | 5,000 |
| NF-L | 0.0014 | 0.009 | 0.8 | 400,000 | 5,000 |
| NF-L Revised | 0.0014 | 0.2 | 0.8 | 400,000 | 5,000 |
*
Units for rate constants are hr−1.
†
F is bioavailability and is a unit-less ratio. Estimates for F are not available in literature.
Value was stipulated to be 0.8. Actual values are likely to differ.