Table 3 -.

Values of cPRA in IA group subjects (n=13) before transplantation, during transplant follow-up and after graft failure.

Subject	cPRA (%) Pre-ITx	cPRA (%) 1/2 GS	cPRA (%) GF	cPRA (%) 1 year post-GF	cPRA (%) 2 years post-GF	cPRA (%) 3 years post-GF	cPRA (%) 4 years post-GF	cPRA (%) 5 years post-GF	cPRA (%) 6 years post-GF	cPRA (%) 7 years post-GF	cPRA (%) 8 years post-GF	cPRA (%) 9 years post-GF	cPRA (%) 10 years post-GF	cPRA (%) 11 years post-GF	cPRA (%) 12 years post-GF	cPRA (%) 13 years post-GF	cPRA (%) 14 years post-GF	cPRA (%) 15 years post-GF
#1	0	0	89	89	n/a	n/a	n/a	n/a	90	78	27	n/a	79	82	83	82	82	85
#2	0	0	0	n/a	n/a	n/a	n/a	n/a	n/a	63	59	8	0b	56	56	56	56	83
#3	22	22	24	n/a	n/a	n/a	n/a	75	84	0	0	0	0	0	0	Enrolleda	Enrolleda	Enrolleda
#4	0	0	99	99	n/a	n/a	92	96	23	23	23	23	64	64	0	0	0	Enrolleda
#5	0	0	0	n/a	n/a	0	0	0	0	0	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP
#6	0	0	0	n/a	n/a	n/a	n/a	99	98	81	81	82	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LFTUP
#7	0	0	96	n/a	n/a	n/a	n/a	n/a	100	0b	86	93	95	89	89	91	79	89
#8	0	0	0	n/a	n/a	n/a	0	0	0	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda
#9	0	0	0	0	0	0	29	24	3	8	0	0	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda	Enrolleda
#10	0	0	0	24	11	4	4	11	n/a	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP
#11	0	0	22	n/a	n/a	n/a	n/a	n/a	22	30	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP	LTFUP
#12	0	0	0	n/a	n/a	n/a	n/a	n/a	n/a	0	0	0	0	n/a	0	0	0	Enrolleda
#13	n/a	0	0	n/a	n/a	70	24	24	0	0	0	0	0	0	0	Enrolleda	Enrolleda	Enrolleda

Abbreviations: IA, islet transplantation alone; ITx, islet transplant; ½ GS, half-life graft survival; GF, graft failure; cPRA, calculated panel-reactive antibody; LTFUP lost to follow-up; n/a data not available.

^aEnrolled: patients have not reached this evaluation point (still enrolled in the protocol).

^bPresence of antigen specific antibodies and values of MFI below 3000, resulting in cPRA “0”.