Table 1.
Cancer type, treatment, and family history of patients presenting with incidental findings identified through NGS-MGP testing on peripheral blood leukocyte (PBL)-derived DNA.
| Patient ID | Sex | Ethnicity | Cancer | Age at Cancer Diagnosis | History of Systemic Chemotherapy (Y/N) | WBC (109) | Family Cancer Hx |
|---|---|---|---|---|---|---|---|
| 2 | F | Ashkenazi Jewish | Breast | 52 | Y | 6.8 | FDR: 3 (Melanoma + Prostate; Basal Cell Carcinoma; Breast + Melanoma); SDR: 7 (Kidney; Prostate; Breast; Breast; Colon + Melanoma; Ovary; Breast) |
| Breast | 63 | ||||||
| 3 | F | English | Serous Ovarian | 78 | Y | 4.9 | FDR: 1 (Cervical) |
| 5 | F | English/Scottish/ German | Serous Ovarian | 68 | NA | NA | NA |
| 6 | F | British | None | NA | N | 7.5 | FDR: 1 (Ovarian); SDR: 1 (Breast) |
| 7 | F | Caucasian | Ductal Carcinoma In-Situ | 37 | N | 6.2 | SDR: 13 (Breast; Lung; Lung; Breast; Breast; Breast; Breast; Breast; Lung + Liver; Pancreas; Pancreas; Pancreas; Brain) |
| 8 | F | Irish/ English | Hodgkin’s Lymphoma | 21 and 29 | Y | 7.5 | SDR: 4 (Sarcoma; Lung; Prostate; Breast) |
| Thyroid Cancer | 40 | ||||||
| Breast | 65 | ||||||
| Serous Ovarian | 70 | ||||||
| 10 | F | Sephardic Jewish | Serous Ovarian | 54 | Y | 12.2 | FDR: 2 (Testicular; Prostate + Thyroid) |
| 11 | F | European, Ashkenazi Jewish | Breast | 59 | Y | 84.9 | FDR: 4 (Basal Cell Carcinoma; Bone; Basal Cell Carcinoma; Breast); SDR: 4 (PSU; Breast; Leukemia; Hodgkin’s Lymphoma) |
| Chronic Lymphoblastic Leukemia | 72 | ||||||
| 12 | F | Caucasian | IgA Kappa Myeloma | 72 | Y | 5.6 | FDR: 3 (Polyps; Polyps; Gastrointestinal) SDR: 5 (Leukemia; Lymphoma; Melanoma; Breast: Breast) |
| Colon | 79 | ||||||
| 13 | F | West Indies | Breast | 51 | Y | 5.8 | FDR: 1 (Breast + Lung); SDR: 5 (Breast; Ovarian; Lung; Lung; Ovarian) |
| 14 | F | Sri Lankan | Serous Ovarian | 80 | Y | NA | FDR: 1 (Stomach); SDR: 4 (Brain; Breast; Breast; Stomach) |
| 15 | F | Dutch | Serous Ovarian | 70 | NA | NA | None |
| 16 | F | East Indian | Ovarian | 60 | Y | 4.9 | SDR: 1 (Cervical) |
| 18 | F | Latvian, French, Ashkenazi Jewish | Serous Ovarian | 78 | Y | 8.1 | FDR: 1 (Small Cell); SDR: 2 (Bladder; Small Cell Bladder) |
| 19 | F | British/French | Colorectal Adenomas | 62 | N | 10.6 | FDR: 1 (Ovarian); SDR:1 (Colon) |
| 22 | F | Slovenian | Polycythemia Vera | 52 | Y | 7.2 | FDR 1: (Colon) |
| Serous Uterine | 70 | ||||||
| 24 | F | English/Irish | Breast | 38 | Y | 8.0 | FDR: 1 (Peritoneal); SDR: 7 (Breast, Breast; Breast; Breast; Breast+ Ovarian; Colon; Brain) |
| Ovarian | 54 | ||||||
| Breast | 63 | ||||||
| Lung | 71 | ||||||
| 27 | F | English/Scottish | Breast | 48 | Y | 6.8 | FDR: 2 (Breast; Gastric); SDR: 2 (Brain; Breast) |
| Breast | 56 | ||||||
| Breast | 67 | ||||||
| 29 | M | Eastern European | Prostate | 53 | Y | 10.4 | FDR: 2 (Breast; Melanoma); SDR: 3 (Leukemia; Leukemia + Prostate; Breast) |
| 33 | F | French Canadian | Breast | 35 | Y | 4.1 | FDR: 1 (Bladder); SDR: 6 (Bone; Lung; Lung + Liver; Skin; Breast; Lung) |
| Serous Ovarian | 56 | ||||||
| Ovarian | 58 | ||||||
| 40 | F | Caucasian | >100 Adenomas | 29 | N | 5.3 | FDR: 1 (Breast) |
| 41 | F | Scottish | Breast | 77 | Y | 7.3 | FDR: 2 (Lung; Lung); SDR: 5 (Breast; Breast; Unknown; Unknown; Unknown) |
| 42 | M | Caucasian | Breast (male) | 72 | Y | 5.6 | FDR: 1 (Skin); SDR: 5 (Skin; Skin; Pancreas; Brain; Brain) |
| 43 | F | Scottish/Irish | Breast | 55 | Y | 10.7 | FDR: 2 (Thyroid; Pancreas); SDR: 2 (Breast; Breast + Ovary) |
WBC White Blood Cell Count, Hx History, FDR First Degree Relative, SDR Second Degree Relative, Y/N Yes/No, NA Not available.