Table 1.
Dataset | Category | Population | # Samples (Cases) | # Samples (Control) | # Samples (Total) |
---|---|---|---|---|---|
1 Staphylococcus aureus infection | Bacterial Infection | Pediatric | 99 | 44 | 143 |
2 Sepsis | Bacterial Infection | Adult | 35 | 12 | 47 |
3 Tuberculosis | Bacterial Infection | Adult | 23 | 11 | 34 |
4 Influenza | Viral Infection | Pediatric | 25 | 14 | 39 |
5 RSV | Viral Infection | Pediatric | 70 | 14 | 84 |
6 HIV | Viral Infection | Adult | 28 | 35 | 63 |
7 Systemic lupus erythematosus | Autoimmune | Pediatric | 55 | 14 | 69 |
8 Multiple sclerosis | Autoimmune | Adult | 34 | 22 | 56 |
9 Juvenile dermatomyositis | Autoimmune | Pediatric | 40 | 9 | 49 |
10 Kawasaki disease | Autoinflammatory | Pediatric | 21 | 23 | 44 |
11 Systemic onset juvenile idiopathic arthritis | Autoinflammatory | Pediatric | 62 | 23 | 85 |
12 COPD | Inflammatory | Adult | 19 | 24 | 43 |
13 Melanoma | Malignancy | Adult | 22 | 5 | 27 |
14 Pregnancy | Physiologic variant | Adult | 25 | 20 | 45 |
15 Liver transplant recipients | Immunosuppressed | Adult | 94 | 30 | 124 |
16 B-cell deficiency | Immunodeficiency | Adult | 20 | 13 | 33 |
Sixteen distinct datasets were used as the input for module repertoire construction. Each dataset corresponds to a different condition or physiological state and comprises both cases and matched controls. Each dataset was processed as a single batch at the same facility with the data generated using Illumina HumanHT-12 v3.0 Gene Expression BeadChips. The collection comprises a total of 985 individual transcriptome profiles.