Table 1.
Differential expression of endothelial and mitochondrial pathways by ontology analysis.
| Gene set name | FDR q-value | Up or down in PAH |
|---|---|---|
| ATP_METABOLIC_PROCESS | 1.41E−16 | Up |
| MITOCHONDRION_ORGANIZATION | 1.44E−16 | Up |
| OXIDATIVE_PHOSPHORYLATION | 2.49E−15 | Up |
| ELECTRON_TRANSPORT_CHAIN | 2.99E−15 | Up |
| OXIDATION_REDUCTION_PROCESS | 4.87E−15 | Up |
| ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT | 4.07E−14 | Up |
| CELLULAR_RESPIRATION | 2.62E−13 | Up |
| RESPIRATORY_ELECTRON_TRANSPORT_CHAIN | 6.87E−13 | Up |
| MITOCHONDRIAL_ELECTRON_TRANSPORT_NADH_TO_UBIQUINONE | 6.97E−13 | Up |
| ENERGY_DERIVATION_BY_OXIDATION_OF_ORGANIC_COMPOUNDS | 1.26E−12 | Up |
| NADH_DEHYDROGENASE_COMPLEX_ASSEMBLY | 4.90E−12 | Up |
| MITOCHONDRIAL_RESPIRATORY_CHAIN_COMPLEX_ASSEMBLY | 5.96E−12 | Up |
| MITOCHONDRIAL_TRANSLATIONAL_TERMINATION | 2.96E−11 | Up |
| MITOCHONDRIAL_TRANSLATION | 9.39E−09 | Up |
| MITOCHONDRIAL_GENE_EXPRESSION | 9.13E−08 | Up |
| TUBE_DEVELOPMENT | 3.66E−11 | Down |
| TUBE_MORPHOGENESIS | 1.19E−10 | Down |
| BLOOD_VESSEL_MORPHOGENESIS | 5.99E−10 | Down |
| ENDOTHELIAL_CELL_MIGRATION | 1.43E−08 | Down |
| OXIDATIVE_PHOSPHORYLATION | 3.12E−07 | Down |
| ENDOTHELIUM_DEVELOPMENT | 3.10E−05 | Down |
| ATP_SYNTHESIS_COUPLED_ELECTRON_TRANSPORT | 4.83E−05 | Down |
| RESPIRATORY_ELECTRON_TRANSPORT_CHAIN | 1.30E−04 | Down |
| REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION | 1.54E−04 | Down |
| ATP_METABOLIC_PROCESS | 1.88E−04 | Down |
| BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION | 2.21E−04 | Down |
| POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION | 2.35E−04 | Down |
| SPROUTING_ANGIOGENESIS | 2.52E−04 | Down |
FDR false discovery rate.