Table 4.
Univariate and multivariate associations of total life adversity, adversity during sensitive periods, and mental health with the endotoxin tolerance phenotype.
| Endotoxin tolerance immunosuppressive phenotype | |||
|---|---|---|---|
| β | t-test | p-value | |
| Univariate associations (Mental health) | |||
| PTSD symptom severity (PSSI), df = 40 | 0.115 | 0.730 | 0.470 |
| Depressive symptoms (CESD-R), df = 40 | 0.189 | 1.216 | 0.231 |
| Multivariate model 1 (df = 36) | |||
| Total life adversity | −0.442 | −2.607 | 0.031* |
| Early life adversity | 0.118 | 0.741 | 0.464 |
| Adversity in pregnancy | 0.213 | 1.375 | 0.178 |
| Multivariate model 2 (df = 36) | |||
| Total life adversity | −0.374 | −2.321 | 0.026* |
| PTSD symptom severity (PSSI) | 0.034 | 0.143 | 0.887 |
| Depressive symptoms (CESD-R) | 1.182 | 0.805 | 0.426 |
Univariate associations show that neither mental health factor is significantly associated with the phenotype in regression analyses (equivalent here to Pearson correlations). Multivariate models 1 and 2 demonstrate the relative independent association of total life adversity from adversity during sensitive periods and from mental health symptoms.
PSSI PTSD symptom scale interview, total score, CESD-R Center for Epidemiologic Studies depression scale, total score.
*p ≤ 0.05, †p ≤ 0.10.