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. 2021 Jul 19;11:14680. doi: 10.1038/s41598-021-92779-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Multiple pathways aberrantly-regulated revealed by enrichment analyses. Functional enrichment results based on GO (a), KEGG (b) and Reactome (c) database were presented as dot bubble graphs (pathways with ascending significance from top to bottom), GSEA results revealed phototransduction pathway as the most prominently enriched process, up-regulated in response to ER stress: enrichment plot (d) profiling the running enrichment score (ES) and positions of gene set members on the rank ordered list, along with the heatmap (e) showing expression levels of the probed genes involved in the pathway of phototransduction. C/CTRL: Control, T/TUNI: Tunicamycin. The concealed part of the pathways’ names in (a): signal transducer activity, downstream of receptor; ATP-dependent microtubule motor activity, minus-end-directed; oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor; signal transducer, downstream of receptor, with serine/threonine kinase activity; oxidoreductase activity, acting on peroxide as acceptor (from top to bottom); in (c): TCA cycle and respiratory electron transport; respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.