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. 2021 Jul 6;8:692540. doi: 10.3389/fcvm.2021.692540

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Copyright © 2021 Liu, Huang, Zhang, Shui, Liu, Wu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lacidipine inhibited endothelial senescence and promoted CXCR7 expression. Cultured ECs were treated with Lacidipine, followed by bleomycin stimulation (senescence induction). Cell senescence was determined through β-galactosidase staining (A). Immunofluorescence assay was applied to determine the protein expression of CXCR7 (B). Western blot was performed to analyze the protein expression of CXCR7, P38, and p-P38 (C). qPCR (D) and Western blot were performed to analyze the levels of VCAM1, Endoglin, MCP-1, IL-6, P16, and P21 (E). (Data are mean ± SD of three independent experiments. ***p < 0.001, compared with the control group; ###p < 0.001, compared with the bleomycin group).