Fig. 5.

CLEs and FLEs encode B vitamin and cofactor biosynthetic pathways. CLEOA, CRt, CLEAA, FLE-Om (Francisella endosymbiont of Ornithodoros moubata; LVCE00000000), FLE-Am (Francisella endosymbiont of Amblyomma maculatum; LNCT00000000), and Francisella persica (FLE in Argas arboreus; NZ_CP013022) contain intact pathways for the synthesis of B vitamins and cofactors. Enzymes catalyzing each step are labeled with gene names and EC numbers. Blocks with no color indicate that a functional copy of a gene was not detected in that genome. Depictions of metabolic pathways modified from Gerhart et al. (2018).