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. 2021 Jul 6;11:709579. doi: 10.3389/fonc.2021.709579

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Copyright © 2021 Xu, Tian, Liu, Anwaier, Su, Zhu, Wan, Shi, Wei, Qu, Zhang and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cluster 3 exhibited distinct clinical malignant biological phenotype and suppressive immune microenvironment than cluster 1&2. (A) We integrated cluster 1&2 and made comparisons of survival benefits between m⁶AMS cluster 3 (n = 135) and cluster 1&2 (n = 395) using Kaplan–Meier method. (B) Volcano plots were constructed using fold-change values and adjusted P. The red point represents the up-regulated and the blue point indicates the down-regulated m⁶A regulators with statistical significance between cluster 3 and cluster 1&2.