Table 2.

Pregnancy outcome and birth outcomes of studies included in the systematic review

Reference	Exposed pregnancies	Spontaneous abortion	IUFDa)	Total birth	Normal birth	Congenital malformationsb)	Major congenital malformations	Outcome of major malformation
Lammer et al. [2]	154	12 (7.8)	12	35	26	9	9	Cranium and face, heart, thymus, CNS, combination
Dai et al. [3]	433	21 (4.8)	0	94	61	33	26	Cardiovascular, craniofacial, CNS
Mitchell et al. [19]	402	76 (18.9)c)	1	32	25	7	6	Ear, eye craniofacial, brain, hypoplastic scrotum, confluent eyebrows
Cheetham et al. [16] Bérard et al. [15]	17 90	2 (11.8) 3 (3.3)	0 2	1 9	1 6	0 3	0 1	NA Congenital anomaly of face and neck diagnosed at 3 years old
Garcia-Bournissen et al. [17]	43	1 (2.3)	0	14	12	NA	2	Anotia, heart malformation
Schaefer et al. [20]	91	5 (5.5)	0	18	15d)	3	1	Ventricular septal defect
Shin et al. [10]	29	3 (10.3)	0	9	8	1	1	Polydactyly of fingers
Zomerdijk et al. [21]	51	NA	3	50	48d)	2	2	Neural tube defect, major congenital anomaly not further specified
Henry et al. [18]	1,473	290 (19.7)	0	118	107	11	11	NA

Values are presented as number (%).

IUFD, intrauterine fetal death; CNS, central nervous system; NA, not available.

^a)Fetal demise above 20 weeks of gestation;

^b)Major malformation+minor malformations;

^c)Added ectopic pregnancy;

^d)Include twins.