Table 2.
Prognostic values of clinical factors and C1QC+ and SPP1+ TAMs gene signatures in cervical cancer.
| Overall | HR (univariable) | HR (multivariable)| | |||
|---|---|---|---|---|---|
| (n=75) | HR (95% CI) | P | HR (95% CI) | P | |
| Age, years | |||||
| Mean (SD) | 46 | 1.03 (1.00–1.07) | 0.067 | 1.06 (0.99–1.12) | 0.078 |
| FIGO stage | |||||
| I-IB1 | 36 | ||||
| IB2-IVA | 41 | 1.95 (0.79–4.79) | 0.146 | 1.20 (0.30–4.77) | 0.793 |
| Histological type | |||||
| SCC | 69 | ||||
| AS | 1 | NA | NA | NA | NA |
| Other | 12 | 0.24 (0.03–1.76) | 0.159 | 0.37 (0.03–4.03) | 0.416 |
| Histological grade | |||||
| G1 | 5 | ||||
| G2 | 34 | 0.53 (0.07–4.33) | 0.554 | 0.08 (0.00–1.28), | 0.074 |
| G3 | 37 | 0.90 (0.11–7.21) | 0.924 | 0.03 (0.00–0.91) | 0.044 |
| GX | 6 | 4.78 (0.51–45.22) | 0.172 | 0.39 (0.01–12.22) | 0.595 |
| Pathologic M | |||||
| M0 | 30 | ||||
| M1 | 2 | 2.88 (0.35–23.84) | 0.327 | NA | NA |
| MX | 34 | 0.71 (0.26–1.97) | 0.514 | 0.10 (0.01–1.10) | 0.059 |
| Pathologic N | |||||
| N0 | 40 | ||||
| N1 | 18 | 2.76 (0.84–9.07) | 0.094 | 0.98 (0.20–4.76) | 0.981 |
| NX | 10 | 5.48 (1.52–19.76) | 0.009 | 4.91 (0.35–69.22) | 0.238 |
| C1QC_SPP1 | |||||
| High_Low | 40 | ||||
| Low_High | 42 | 4.08 (1.50–11.09) | 0.006 | 8.40 (1.33–52.94) | 0.023 |
TAMs, tumor-associated macrophages; HR, hazard ratio; CI, confidence interval; SD, standard deviation; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous cell carcinoma; AS, adenosquamous cell carcinoma; C1QC_SPP1, C1QC+ and SPP1+ TAMs gene signatures; High_Low, C1QChigh and SPP1low TAMs gene signatures; Low_High, C1QClow and SPP1high TAMs gene signatures.
NA, Not available.