Table 1.
Impact of SNPs in LBP gene on infectious diseases, sepsis and septic complications.
| dpSNP ID | Disease | SNP Carrier | Main statement | Reference |
|---|---|---|---|---|
| -(Cys98→Gly) | sepsis | – | Gly98 allele may contribute to an increased predisposition to sepsis in male patients | (43) |
| rs2232582 | septic complications after HCT | Heterozygous | C allele associated with a 2-fold higher risk for GN bacteremia after HCT. | (21) |
| Infective endocarditis | Heterozygous | T allele may associate with high risk for infective endocarditis. | (44) | |
| rs2232596 | Infective endocarditis | Homozygous | G allele may associate with high risk for infective endocarditis. | (44) |
| a 4-SNP haplotype: | sepsis | Homozygous | The haplotype associated with increased risk for sepsis and higher mean levels of serum LBP. | (45) |
| rs1780616-C | ||||
| rs5741812-A | ||||
| rs2232571-T | ||||
| rs1780617-A | ||||
| rs2232571 | septic complications after HCT | Heterozygous | C allele was associated with higher median basal serum LBP levels, a 3-fold increase in the risk of death prior to discharge, and a 5-fold increase in mortality risk. | (21) |
| hematopoietic cell transplantation | Heterozygous | C allele was associated with higher median basal serum LBP levels. | (46) | |
| rs2232613 | hematopoietic cell transplantation | Heterozygous | Showed association with lower plasm LBP concentrations but higher efficiency in endotoxin extraction and transfer to MD-2. | (46) |
| pneumonia and sepsis | Heterozygous | Carriage of T allele impaired bacterial ligands binding capacity and cytokines-induction function and exhibited a higher risk for mortality in the course of septic complications and pneumonia. | (47) | |
| rs2232618 | trauma | – | Generated mutant protein had an enhanced binding capacity with CD14. C allele contributed to higher incidence and development of sepsis. | (48) |
| Sepsis | Homozygous | A combination with additional four SNPs was associated with sepsis in children. | (49) | |
| trauma | Heterozygous | C allele was associated with and higher incidence and development of sepsis. | (50) | |
| bacterial vaginosis | – | It was marginally significantly associated with Carriage of A. vaginae during early pregnancy. | (51) |