Table 2.

Effect of SNP in LBP-gene atopy, metabolic diseases and cancer.

Disease	dpSNP ID	Effect	Reference
atopy	rs2232596	It was one of the predictors of total IgE at 1-2 years old in the three-factor model.	(56)
	rs745144	It was one of the predictors of total IgE at 6-8 years in the three-factor model.
	rs6025083	It was one of the predictors of specific IgE to indoor allergens at 6–8 years old in the three-factor model.
asthma	rs2232580	Two SNPs associated with atopy in children with a family history of allergies.	(57)
	rs5741812
	rs12624843	It was associated with airway hyperresponsiveness (AHR).
type 2 diabetes	rs1739654	Four SNPs were significantly correlated with susceptibility to type 2 diabetes. Rs2232592 indicated a risk for diabetes with the history of obesity and/or earlier age of onset.	(58)
	rs2232578
	rs2232592 rs1780627
HIV-1/HAART-associated lipodystrophy syndrome (HALS)	rs2232582	It had significant association with HALS, T allele having greater prevalence of HALS.	(59)
myocardial infarction	G292→T	It had no significant association with a risk of myocardial infarction.	(60)
	rs2232618
	(Pro436Leu)
cerebral infarction	rs2232582	Two SNPs had significant association with Carotid intima-media thickness (CIMT) in Chinese, but both were not associated with risk of atherosclerotic cerebral infarction.	(61)
	(291T>C)
	rs2232618
	(1341T>C)
colorectal carcinoma	rs2232596	G allele had a significant association with an increased CRC risk.	(62)
colorectal neoplasia	rs1780617	G allele was significantly associated with the risk of CRC and adenoma.	(63)
gastric cancer	rs2232578	It was associated with the risk of GC in combination with H. pylori infection.	(64)
glioma	rs2232580	It to glioma risk and susceptibility.	(65)