TABLE 1.

IC₅₀ and Kd values of GZD824 against FGFR1–4

FGFRs	Kd (nM)	IC50 (nM)
FGFR1	7.3 ± 0.3	4.14 ± 0.96
FGFR2	15.5 ± 3.5	2.77 ± 0.082
FGFR3	17.0 ± 1.4	8.10 ± 0.15
FGFR4	19.0 ± 1.4	30.27 ± 21.66

Binding activities were performed by KINOMEscan™ assay. Kinase inhibitory was performed by Z′‐Lyte method‐based FRET principle.