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. 2021 Jun 22;10(14):4710–4720. doi: 10.1002/cam4.3963

FIGURE 2.

FIGURE 2

Further demonstration of selected pivotal genes supports their crucial role in the progression and prognosis of melanoma. A ceRNA (miRNA‐lncRNA‐mRNA) network involved in melanoma was identified. (A) The results of survival analysis display a remarkable distinction in survival between the IL2RA low and IL2RA high groups, between the IL2RG low and IL2RG high groups, between the IL7R low and IL7R high groups, and between the IFNG low and IFNG high groups. (B) RT‐PCR results of the four genes in human tissues show evident bias in mRNA expression between normal tissues and matched melanoma tissues. *represents a significant statistical difference. (C) Parts of the correlation analysis between DE miRNA and DE mRNA, between DE miRNA and DE lncRNA, and between DE mRNA and DE lncRNA are presented. (D) IL7R‐associated and IL2RA‐associated ceRNAs are displayed in the picture. T shape represents an inhibitory effect, while arrow shape represents an activating effect