TABLE 2.
Unadjusted survival analysis of proximal gastric cancer by different regions and races
| Total | p value | the US | p value | China | p value | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | HR | 95%CI | HR | 95%CI | ||||
| Region | |||||||||
| China | 1 | ‐ | ‐ | ||||||
| the US | 4.337 | 4.123–4.562 | <0.001 | ||||||
| Race | |||||||||
| Chinese | 1 | 1 | ‐ | ||||||
| Black | 4.538 | 4.266–4.827 | <0.001 | 1.431 | 1.284–1.596 | <0.001 | |||
| White | 3.716 | 3.549–3.890 | <0.001 | 1.173 | 1.173–1.298 | 0.002 | |||
| Others | 3.28 | 3.071–3.504 | <0.001 | 1.036 | 0.927–1.158 | 0.533 | |||
| Age | |||||||||
| <45 | 1 | 1 | 1 | ||||||
| 45–54 | 0.936 | 0.878–0.997 | 0.039 | 0.993 | 0.930–1.061 | 0.843 | 0.689 | 0.556–0.854 | 0.001 |
| 55–64 | 0.93 | 0.877–0.986 | 0.015 | 1.049 | 0.987–1.116 | 0.126 | 0.553 | 0.453–0.675 | <0.001 |
| 65–74 | 1.088 | 1.027–1.152 | 0.004 | 1.160 | 1.092–1.232 | <0.001 | 0.638 | 0.522–0.779 | <0.001 |
| >=75 | 1.766 | 1.668–1.869 | <0.001 | 1.675 | 1.578–1.778 | <0.001 | 0.836 | 0.654–1.070 | 0.154 |
| Sex | |||||||||
| Female | 1 | 1 | 1 | ||||||
| Male | 0.908 | 0.885–0.932 | <0.001 | 0.963 | 0.937–0.989 | 0.005 | 0.958 | 0.839–1.093 | 0.519 |
| Year | |||||||||
| 1996–2000 | 1 | 1 | 1 | ||||||
| 2001–2005 | 0.919 | 0.887–0.952 | <0.001 | 0.952 | 0.919–0.987 | 0.007 | 1.034 | 0.737–1.451 | 0.845 |
| 2006–2010 | 0.731 | 0.706–0.758 | <0.001 | 0.863 | 0.832–0.894 | <0.001 | 0.679 | 0.491–0.939 | 0.019 |
| 2011–2016 | 0.61 | 0.589–0.631 | <0.001 | 0.788 | 0.760–0.817 | <0.001 | 0.447 | 0.323–0.618 | <0.001 |
| Grade | |||||||||
| Well differentiated | 1 | 1 | 1 | ||||||
| Moderately differentiated | 1.307 | 1.227–1.392 | <0.001 | 1.333 | 1.251–1.421 | <0.001 | 3.686 | 1.959–6.934 | <0.001 |
| Poorly differentiated | 1.693 | 1.592–1.800 | <0.001 | 1.800 | 1.692–1.914 | <0.001 | 5.599 | 2.999–10.451 | <0.001 |
| Undifferentiated | 2.071 | 1.877–2.285 | <0.001 | 1.859 | 1.683–2.053 | <0.001 | 30.572 | 13.729–68.077 | <0.001 |
| Linits plastica | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 0.69 | 0.580–0.822 | <0.001 | 0.658 | 0.547–0.791 | <0.001 | 0.421 | 0.249–0.713 | 0.001 |
| Signet ring cell carcinoma | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 0.923 | 0.892–0.956 | <0.001 | 0.857 | 0.827–0.888 | <0.001 | 0.986 | 0.858–1.132 | 0.836 |
| AJCC T,7thed | |||||||||
| T1 | 1 | 1 | 1 | ||||||
| T2 | 0.931 | 0.890–0.975 | 0.002 | 0.915 | 0.874–0.958 | <0.001 | 1.585 | 1.025–2.451 | 0.038 |
| T3 | 0.871 | 0.835–0.907 | <0.001 | 1.034 | 0.990–1.079 | 0.130 | 3.792 | 2.728–5.270 | <0.001 |
| T4 | 1.108 | 1.056–1.162 | <0.001 | 2.033 | 1.928–2.144 | <0.001 | 6.708 | 4.856–9.265 | <0.001 |
| AJCC N,7thed | |||||||||
| N0 | 1 | 1 | 1 | ||||||
| N1 | 1.303 | 1.261–1.347 | <0.001 | 1.255 | 1.213–1.297 | <0.001 | 1.938 | 1.574–2.386 | <0.001 |
| N2 | 0.89 | 0.843–0.939 | <0.001 | 1.115 | 1.052–1.182 | <0.001 | 2.835 | 2.339–3.437 | <0.001 |
| N3 | 0.93 | 0.874–0.989 | 0.022 | 1.407 | 1.301–1.523 | <0.001 | 5.029 | 4.220–5.993 | <0.001 |
| AJCC M,7thed | |||||||||
| M0 | 1 | 1 | 1 | ||||||
| M1 | 3.401 | 3.301–3.505 | <0.001 | 2.838 | 2.752–2.927 | <0.001 | 4.831 | 4.219–5.530 | <0.001 |
| AJCC TNM, 7thed | |||||||||
| I | 1 | 1 | 1 | ||||||
| II | 1.168 | 1.113–1.226 | <0.001 | 1.296 | 1.234–1.362 | <0.001 | 2.336 | 1.699–3.212 | <0.001 |
| III | 1.206 | 1.149–1.265 | <0.001 | 1.579 | 1.499–1.664 | <0.001 | 6.559 | 4.931–8.724 | <0.001 |
| IV | 4.255 | 4.078–4.4438 | <0.001 | 3.942 | 3.776–4.116 | <0.001 | 22.752 | 16.790–30.830 | <0.001 |
| Surgery | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No | 3.588 | 3.501–3.678 | <0.001 | 3.198 | 3.116–3.281 | <0.001 | 2.915 | 2.619–3.245 | <0.001 |
| Unknown | 2.33 | 2.114–2.567 | <0.001 | 1.941 | 1.761–2.139 | <0.001 | |||
| Lymphadenectomy with at least 15 lymph nodes | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 1.469 | 1.414–1.527 | <0.001 | 1.186 | 1.138–1.237 | <0.001 | 1.162 | 1.025–1.316 | 0.019 |
| Number positive nodes | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 0.616 | 0.593–0.639 | <0.001 | 0.528 | 0.507–0.549 | <0.001 | 0.420 | 0.365–0.483 | <0.001 |
| Neo/adjuvant Chemotherapy a | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 0.871 | 0.838–0.904 | <0.001 | 0.990 | 0.951–1.031 | 0.633 | 0.888 | 0.785–1.003 | 0.057 |
| Neo/adjuvant Radiation a | |||||||||
| Yes | 1 | 1 | 1 | ||||||
| No/unknown | 0.782 | 0.752–0.814 | <0.001 | 1.038 | 0.997–1.082 | 0.070 | 0.761 | 0.580–0.998 | 0.048 |
aNeo/adjuvant Chemotherapy: Neoadjuvant chemotherapy OR/AND adjuvant chemotherapy.
Neo/adjuvant Radiation: Neoadjuvant radiation OR/AND adjuvant radiation.