TABLE 2.
Population pharmacokinetic parameters of docetaxel
| Pharmacokinetic parameters | Estimate of original dataset (RSE, %) | Median of bootstrap replicates (2.5–97.5% CI), N = 1100 |
|---|---|---|
| Clearance (L/h) | 18 (20) | 17.59 (6.25–23.07) |
| Volume of compartment 1 (L) | 5.8 (10) | 5.66 (2.90–6.86) |
| Volume of compartment 2 (L) | 2.65 (15) | 2.79 (1.97–4.58) |
| Volume of compartment 3 (L) | 468 (28) | 478.8 (290.36–1045.70) |
| Inter‐compartmental clearance 1–2 (L/h) | 6.49 (37) | 6.74 (3.44–28.32) |
| Inter‐compartmental clearance 1–3 (L/h) | 29.7 (14) | 30.20 (23.08–42.13) |
| Inter‐patient variability | ||
| Clearance (%) | 45.3 (20) | 45.8 (29.84–83.27) |
| Inter‐compartmental clearance 1–3 (%) | 53.5 (10) | 51.9 (41.14–63.13) |
| Volume of compartment 3 (%) | 78.5 (17) | 75.42 (44.95–101.56) |
| Residual variability | ||
| Proportional error (%) | 30.93 (5) | 30.6 (27.71–33.83) |
Abbreviations: CI, confidence interval; RSE, relative standard error.