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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Acc Chem Res. 2021 May 13;54(11):2649–2659. doi: 10.1021/acs.accounts.1c00154

Figure 4.

Figure 4

Proposed heme speciation in the presence of hemozoin inhibitors. Drugs targeting the hemozoin pathway (i) cause a decrease in hemozoin (Hz) formation via adsorption, resulting in a build-up of exchangeable heme (H(aq)). These drugs form complexes (HD(aq)) with free heme (ii), that are likely responsible for parasite killing (red arrow). Green arrows indicate the shift in equilibria in the presence of a Hz inhibitor. Precipitation of free heme (H(s)) and heme-drug complexes (HD(s)) represent competing processes (grey) that depend on their solubility products (Ksp).