Figure 1.

Structure of mitochondrial complex I from Arabidopsis. Above: CryoEM density; below: atomic model. The 14 core subunits that are conserved in complex I in bacteria and eukaryotes are drawn in shades of blue; the accessory subunits in shades of green; the three subunits of the carbonic anhydrase domain in yellow, light orange and orange; subunits of the bridge domain in pink, purple, and red. Subunit nomenclature as for bovine complex I (Walker et al., 1992). Unknown (unk) refers to one subunit in the membrane arm that was not assigned due to limited amino acid sequence information. Figure insets: γ-carbonic anhydrase (γCA) and bridge domains. For EM statistics, see Supplemental Tables S2, S4, and S6.