Table 3. Association Between Hospitalization and Patient Characteristics.
| Characteristic | Patients | OR (95% CI) | ||||
|---|---|---|---|---|---|---|
| Total No. (N = 816) | Hospitalized, No. (%) (n = 364) | Not hospitalized, No. (%) (n = 452) | Unadjusted | Multivariablea | ||
| Year of reported treatment | ||||||
| 2011-2016 | 386 | 185 (50.8) | 201 (44.5) | 1.30 (0.98-1.72) | 1.80 (0.86-3.72) | |
| 2017-2019 | 430 | 179 (49.2) | 251 (55.5) | |||
| IV magnesium therapy | ||||||
| Total | 215 | 190 (52.2) | 25 (5.5) | 25.87 (15.99-41.84) | 9.76 (4.58-20.77) | |
| 2011-2016 | NA | NA | NA | NA | 22.67 (6.26-82.06)b | |
| 2017-2019 | NA | NA | NA | NA | 4.19 (1.99-8.86)b | |
| IV magnesium × year interaction | NA | NA | NA | NA | 5.40 (1.25-23.33) | |
| Initial PRAM score, mean (SD)c | 816 | 6.6 (1.4) | 5.9 (1.0) | 1.64 (1.45-1.86) | 1.21 (0.99-1.46)d | |
| ED disposition PRAM score, mean (SD) | 785 | 4.9 (1.8) | 2.5 (1.3) | 2.70 (2.35-3.11) | 2.24 (1.89-2.65)e | |
| Age ≤5 y | 503 | 232 (63.7) | 271 (60.0) | 1.20 (0.89-1.59) | 1.39 (0.86-2.24) | |
| Sex | ||||||
| Male | 517 | 224 (61.5) | 293 (64.8) | 1.14 (0.86-1.52) | 0.92 (0.57-1.47) | |
| Female | 299 | 140 (38.5) | 159 (35.2) | |||
| Duration of symptoms ≤12 h before arrival | 321 | 147 (40.4) | 174 (38.5) | 1.12 (0.85-1.51) | 1.56 (0.73-1.84) | |
| Past ICU admission for asthma | 79 | 46 (12.1) | 33 (7.7) | 1.74 (1.10-2.80) | 1.66 (0.76-3.66) | |
| Hospitalization for asthma in past year | 197 | 103 (28.3) | 94 (20.8) | 1.58 (1.14-2.20) | 0.89 (0.52-1.52) | |
| Atopy | 493 | 214 (58.8) | 279 (61.7) | 0.82 (0.62-1.10) | 0.79 (0.49-1.28) | |
| Family history of atopy | 603 | 272 (74.7) | 331 (73.2) | 1.10 (0.76-1.47) | 1.06 (0.62-1.81) | |
| Oral corticosteroid therapy before arrival | 145 | 74 (20.3) | 71 (15.7) | 1.36 (0.93-1.98) | 1.12 (0.60-2.08) | |
| Nebulized magnesium therapy | 409 | 172 (47.3) | 237 (52.4) | 0.81 (0.61-1.07) | 0.97 (0.62-1.51) | |
| ≥1 Albuterol treatment after experimental therapy | 510 | 318 (87.4) | 192 (42.5) | 11.82 (8.00-17.47) | 5.94 (3.52-10.01) | |
Abbreviations: ED, emergency department; ICU, intensive care unit; IV, intravenous; NA, not applicable; OR, odds ratio; PRAM, Pediatric Respiratory Assessment Measure.
a
The multivariable regression analysis was adjusted for all variables shown.
b
Adjusted OR for the association between IV magnesium therapy and hospitalization.
c
Details of the PRAM score are given in Table 1. PRAM score measured after initial therapy with corticosteroids, salbutamol, and ipratropium bromide.
d
Per 1-U increase in initial PRAM score.
e
Per 1-U increase in ED disposition PRAM score.