Table 3.
Latent classes based on MS onset symptoms: lifetime comorbidities; frequencies with column % (positive answers); p-values related to χ2-test.
| LC1 | LC2 | LC3 | LC4 | LC5 | LC6 | Total | p-value | |
|---|---|---|---|---|---|---|---|---|
| Multiple symptoms | Gait-balance | Fatigue-weakness | Gait-paralysis | Vision | Paresthesia | |||
| Mononucleosis | 23 (10.7) | 26 (13.0) | 33 (18.6) | 40 (11.6) | 44 (13.5) | 49 (20.9) | 215 (14.4) | 0.007 |
| Angina/Tonsillitis | 74 (36.5) | 55 (28.2) | 73 (43.5) | 89 (26.5) | 115 (36.5) | 82 (35.3) | 488 (33.7) | 0.001 |
| Skin diseases | 43 (20.1) | 23 (11.5) | 35 (19.9) | 55 (16.0) | 39 (12.0) | 31 (13.7) | 176 (15.1) | 0.028 |
| Herpes, fever blisters | 14 (6.5) | 17 (8.5) | 19 (10.8) | 31 (9.0) | 18 (5.5) | 17 (7.3) | 116 (7.8) | 0.313 |
| Cystitis | 28 (13.1) | 22 (11.0) | 26 (14.8) | 30 (8.7) | 33 (10.2) | 20 (8.5) | 159 (10.6) | 0.219 |
| Migraine | 74 (34.6) | 32 (16.0) | 57 (32.4) | 78 (22.7) | 87 (26.8) | 52 (22.2) | 380 (25.5) | 0.000 |
| Gastro-intestinal disorders | 19 (8.9) | 21 (10.5) | 18 (10.2) | 19 (5.5) | 21 (6.5) | 16 (6.8) | 114 (7.6) | 0.186 |
| Atopic diseases | 78 (36.4) | 67 (33.5) | 69 (39.2) | 127 (36.9) | 119 (36.6) | 83 (35.5) | 543 (36.4) | 0.850 |
| Drug allergy | 13 (6.1) | 7 (3.5) | 11 (6.3) | 7 (2.0) | 16 (4.9) | 6 (2.6) | 60 (4.0) | 0.069 |
| Other autoimmune disorders | 25 (11.7) | 11 (5.5) | 8 (4.5) | 11 (3.2) | 14 (4.3) | 8 (3.4) | 77 (5.2) | 0.000 |