. 2021 Jul 19;181(9):1185–1193. doi: 10.1001/jamainternmed.2021.3616

Table 3. Caffeine Metabolism Determined by the CYP1A2 Variant and Risk of Incident Arrhythmia^a.

Arrhythmia type	Hazard ratio (95% CI)^b	P value
All arrhythmia	1.00 (0.96-1.03)	.89
Atrial fibrillation or flutter	0.98 (0.94-1.02)	.22
Supraventricular tachycardia	1.01 (0.91-1.12)	.86
Ventricular tachycardia	0.99 (0.85-1.15)	.91
Premature atrial complex	0.95 (0.59-1.53)	.82
Premature ventricular complex	1.11 (0.92-1.32)	.27

^{^a}

Analyses exclude all family members up to third-degree relatives and are adjusted for age, sex, top 15 principal components, and genotyping array.

^{^b}

Hazard ratios are reported for each increasing number of the allele associated with slower caffeine metabolism.

Table 3. Caffeine Metabolism Determined by the CYP1A2 Variant and Risk of Incident Arrhythmiaa.