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. 2021 Jul 6;9:695900. doi: 10.3389/fcell.2021.695900

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Copyright © 2021 Sykova, Cizkova and Kubinova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hematoxylin–eosin staining of a rat spinal cord with acute balloon-induced spinal cord compression lesion. Spinal cord injury (SCI) only: longitudinal section of the spinal cord with a cavity in the control animal at 6 months after SCI. SCI + hydrogel + mesenchymal stem cells (MSCs): spinal cord at 6 months after a lesion with MSC-seeded HPMA-arginine–glycine–aspartic acid hydrogel implanted at 5 weeks after SCI. Motor test and sensory test: A comparison of motor test (Basso, Beattie, and Bresnahan score) and sensory test (plantar test) in 1–25 weeks after SCI in rats with SCI only, SCI and hydrogel implantation, and SCI with implantation of hydrogel seeded with bone marrow mesenchymal stem cells. Modified from Hejcl et al. (2010).