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. 2021 Jul 6;9:682469. doi: 10.3389/fcell.2021.682469

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Copyright © 2021 Chen, Wei, Yu, Zhang, Huang, Zheng, Wang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome analysis of basal cells treated with baicalin. (A) GO enrichment analysis of development-related pathways in 3D-cultured basal cells. (B) Heatmap analysis of genes related to mammary gland development differentially regulated in response to baicalin. (C) RT-qPCR analysis indicates that baicalin regulates genes related to mammary gland development. Student’s t-test: **P < 0.01; *P < 0.05; ns, not significant. (D) GO enrichment analysis of cell division-related pathways in 3D-cultured basal cells. (E) GSEA (Gene Set Enrichment Analysis) revealed that cell cycle genes are down-regulated by baicalin. (F) GO enrichment analysis of immune response-related pathways in 3D-cultured basal cells. (G) GSEA revealed that NOD-like receptor signaling pathways are down-regulated by baicalin.