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. 2021 Jul 6;9:682469. doi: 10.3389/fcell.2021.682469

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Copyright © 2021 Chen, Wei, Yu, Zhang, Huang, Zheng, Wang and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome analysis of luminal cells treated with baicalin or E2 + PG. (A) Venn diagram showing the overlap of genes up-regulated in 3D-cultured luminal cells treated with baicalin or E2 + PG. (B,C) Enriched pathways from KEGG analysis of genes up-regulated in luminal cells treated with baicalin (B) and E2 + PG (C). (D) Enriched pathways from KEGG analysis of genes in luminal cells up-regulated by both baicalin and E2 + PG. (E) Venn diagram showing the overlap of genes down-regulated in 3D-cultured luminal cells treated with baicalin or E2 + PG. (F,G) Enriched pathways from KEGG analysis of genes down-regulated in luminal cells treated with baicalin (F) and E2 + PG (G). (H) Enriched pathways from KEGG analysis of genes in luminal cells down-regulated by both baicalin and E2 + PG. (I) Representative pathway (breast cancer) down-regulated by baicalin and E2 + PG. (J) Representative pathway (cell cycle) down-regulated in luminal cells by baicalin, but up-regulated in luminal cells by E2 + PG. (K) Representative pathway (Hippo pathway) up-regulated in luminal cells by baicalin and E2 + PG.