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. 2021 Jul 7;22(3):969. doi: 10.3892/etm.2021.10401

Figure 3.

Figure 3

Curcumin promotes miR-30a-5p expression and inhibits PCLAF expression. (A) RT-qPCR was employed to detect the effect of curcumin on miR-30a-5p expression. (B) RT-qPCR (left) and western blotting (right) were used to detect the effect of curcumin on PCLAF mRNA and protein expression. (C) PCLAF expression in PCa samples was analyzed using the Gene Expression Profiling Interactive Analysis database. (D) StarBase database was used to analyze the correlation between miR-30a-5p expression and PCLAF mRNA expression in PCa samples. (E) miR-30a-5p expression and PCLAF mRNA expression in 35 patients with PCa were detected using RT-qPCR and their correlation was analyzed. *P<0.05 vs. normal tissue. ***P<0.001 vs. Control. miR, microRNA; RT-qPCR, reverse transcription-quantitative PCR; PCLAF, PCNA clamp associated factor; PCa, prostate cancer; PRAD, prostate adenocarcinoma; N, normal; T, tumor.