Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 6;9:702112. doi: 10.3389/fcell.2021.702112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Wang, Zhang, Hao, Li, Qi, Xin, Xiao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metabolic features of malignant epithelial cells. (A) Four clusters of malignant epithelial cells originating from four patients with non-small cell lung cancer (NSCLC) were individually re-clustered using t-SNE. (B) Metabolic pathway activity in each cell cluster. Values with statistically non-significant pathway activity (random permutation test, p > 0.05) were shown as blank. (C–E) Boxplot of pathway activity scores of malignant cell clusters originating from patients 1, 2, and 4. (F) Correlation of each malignant cell cluster in metabolic pathway activity scores. Additionally, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. (G) Enrichment results of metabolic pathways in variant genes using gene set enrichment analysis (GSEA). The size of the bubbles represents statistical significance and the shade of the color represents the normalized enrichment score (NES).