Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 7;22(3):970. doi: 10.3892/etm.2021.10402

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Jin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

HP inhibits the JAK1/STAT3 signaling pathway, but has no effect on the NF-κB signaling pathway in LPS-treated BV-2 microglial cells. Cells were pre-treated with 20 µg/ml HP for 30 min, followed by treatment with LPS (1 µg/ml) for the indicated durations. (A) Expression levels of p-JAK1, JAK1, p-STAT3 and STAT3 proteins were detected by western blotting. (B and C) The associated protein expression levels are presented as the means ± SD, ^*P<0.05, ^**P<0.01 and ^***P<0.001. (D) The expression of IκB-α protein was detected by western blotting. (E) The associated protein expression levels are presented as means ± SD. HP, hispidin; LPS, lipopolysaccharide; p, phosphorylated.