Figure 3.

Representative images of hind paws for different clinical scores in mice with collagen-induced arthritis. The upper and lower panels represent the right and left hind paws of different mice, respectively. (A) Normal hind paw (clinical score 0). (B) Erythema and mild swelling confined to the tarsals, ankle joint or paw, with mild swelling in a single limb (clinical score 1). (C) Erythema and mild swelling extending from the ankle to the tarsals or erythema and mild swelling of more than one toe (clinical score 2). (D) Erythema and moderate swelling extending from the ankle to the metatarsal joints, or swelling and obvious erythema of the entire paw (clinical score 3). (E) Erythema and severe swelling of the whole paw, including the ankle, foot and digits; ankylosis of the limb; and dysfunction (clinical score 4).