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. 2021 Jul 6;12:686864. doi: 10.3389/fmicb.2021.686864

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Copyright © 2021 Wang, Wang, Qu, Wang, Jing, Guan, Su, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of SrtA transpeptidation. (A) Chemical structure of Tax. (B) Tax inhibits SrtA cleavage of a fluorogenic peptide substrate (Abz-LPATG-Dnp-NH₂) in a dose-dependent manner in vitro. Each reaction condition was assayed in triplicate from which the IC₅₀ was determined. (C) Recombinant SrtA was treated with 10 × IC₅₀ of Tax and then diluted, after which transpeptidation activity was measured using a FRET assay. Untreated SrtA (Control) represented 100% activity.