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. 2021 Jul 6;12:686864. doi: 10.3389/fmicb.2021.686864

FIGURE 3.

FIGURE 3

Effect of SrtA inhibitor on virulence-related phenotypes in S. aureus Newman strain. (A) Impact of Tax on the ability of S. aureus to adhere to fibrinogen. (B) Biofilm formation of S. aureus in the presence of different concentrations of Tax. (C) Mature biofilms of S. aureus in the presence of different concentrations of Tax. The ΔsrtA group represented the positive control. (D) Tax affects internalization of S. aureus into A549 cells. A549 cells were infected with S. aureus pretreated with different concentrations of Tax then lysed 2 h post-infection. The number of viable S. aureus in the cells was quantified by serial dilution on TSA agar plates. (E) Effects of Tax on S. aureus protein A (SpA) using FITC-labeled rabbit IgG. Error bars represent means ± SD of three replicates. *P < 0.05, **P < 0.01, ***P < 0.001 calculated with a two-tailed Student’s t-test.