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. 2021 Jul 15;15:17534666211028072. doi: 10.1177/17534666211028072

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — IGF1 is the target gene of miR-18a-5p. (a) According to the bioinformatics prediction, miR-18a-5p has a putative complementary sequence in the 3′-UTR of IGF1. (b) The luciferase activity of cells in different groups. *** p < 0.001. (c) The mRNA level of IGF1 in different cell groups. ***p < 0.001, compared with control group. (d) The mRNA level of IGF1 in different cell groups. ***p < 0.001, compared with control group; ^#p < 0.05, ^##p < 0.01, compared with CSE group. (e) The IGF1 mRNA level in different serum samples. ***p < 0.001, compared with non-smoker group; ^###p < 0.01, compared with CSE group. (f) Serum miR-18a-5p showed a negative association with IGF1 level in all smokers. (g) Serum IGF1 showed a negative association with CASC2 level in all smokers. Differences between groups were compared using one-way analysis of variance.

CASC2, cancer susceptibility candidate 2; COPD, chronic obstructive pulmonary disease; CSE, cigarette smoke extract; mRNA, messager RNA; Mut, mutant type; NC, negative control; Wt, wild type.