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The schematic diagram of EA stimulation on T2DM-induced peripheral neuropathy. T2DM-induced hyperglycemia and dyslipidemia lead to the accumulation of AGEs and interaction of AGE-RAGE, which alters a series of inflammatory signals and eventually causes DPN. EA stimulation regulates glycolipid metabolism, which then activates the glyoxalase system and enhances MG detoxification, alleviating the hyperalgesia of DPN.
