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. 2021 Jul 19;28:54. doi: 10.1186/s12929-021-00750-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Multiparametric MRI of the prostate of a 58-year-old man with an elevated serum PSA level of 6.8 ng/mL and cancer-negative biopsy results. A T2WI with low-signal intensity areas in the left and right transition zone (arrows) which were biopsy negative for cancer. B ADC map showing low-signal intensity for the same areas. High-signal intensity for these areas were seen on C high b-value DWI and on pharmacokinetic maps of D K^trans, E K_ep, and F iAUGC. G Middle: MRSI grid and color-coded map overlaid on T2WI. The spectra in the yellow box at the right side and in the green box at the left side represent voxels from histopathology confirmed normal tissue (circles)