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. 2021 Jul 19;28:54. doi: 10.1186/s12929-021-00750-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Multiparametric MRI of the prostate of a 68-year-old man with a serum PSA level of 4.3 ng/ml, who was diagnosed with a biopsy-proven Gleason 3 + 3 cancer region in the left of the transition zone (arrows). The area on the right of the transition zone (arrows) had a cancer-negative biopsy outcome. A T2WI, B ADC map, C high b-value DWI, pharmacokinetic maps of calculated D K^trans, E K_ep, F iAUGC and G MRSI grid and color-coded map overlaid on T2WI, with the red circle representing a voxel with cancer (spectrum in box at the left hand side) and the green circle representing a voxel with normal tissue (spectrum in box at the right hand side)