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Trem1 activated the PI3K/AKT and NF-κB signaling pathway through interacting with SYK. A. Endogenous Trem1 interacted with exogenous SYK. B. Localization of Trem1 and SYK protein in N2a cells was examined by immunofluorescence assay. Scale bar: 100 μm. C. Protein levels of pAKT, PI3K, p-p65, TNF-α, p-SYK and SYK were detected by immunoblotting after OGSD/R.
