TABLE 1.

Validation of primarily in‐clinic computerized and tablet‐based cognitive assessment

Type of validation	Instrument	Authors	Longitudinal/cross‐sectional	Platform	Validation	Effect size	Biomarker	Participants (n)
Biomarker validation	Cogstate C3	Papp et al. (2020)	Cross‐sectional	Tablet	Lower scores were associated with Aβ	Small effect (d = 0.11)	[18F]florbetapir‐PET	4486
	NIHTB‐CB	Snitz et al. (2020)	Cross‐sectional	Tablet	Lower scores were associated with tau in higher Braak regions	Small/moderate effect (β = –0.19 to –0.28)	[11C]PiB‐PET [18F]AV1451‐PET	118
	Cogstate CPAL	Baker et al. (2019)	Longitudinal (36 months)	Personal computer	Lower training effect in Aβ+ CN	Small effect (d = 0.25 to 0.30)	[11C]PiB‐PET	356
	Cogstate CBB	Mielke et al. (2016)	Longitudinal (30 months)	Personal computer	No significant correlation between Aβ and cognition	No effect	[11C]PiB‐PET	464
	CANTAB	Bischof et al. (2016)	Cross‐sectional	Personal computer	Lower memory scores were associated with higher Aβ	Moderate effect (r = 0.47 to 0.48)	[18F]florbetapir‐PET	147
	Cogstate CBB	Lim et al. (2015)	Longitudinal (36 months)	Personal computer	Decline in memory were greater in Aβ+ CN	Small/moderate effect (d = 0.39 to 0.59)	[11C]PiB‐PET	178
Paper/pencil validation	NIHTB‐CB and Cogstate C3	Buckley et al. (2017)	Cross‐sectional	Tablet	Memory tasks was associated with PACC	Moderate/large effect (ρ r = 0.49 to 0.58)	N/A	50

Abbreviations: Aβ, amyloid beta; β, standardized β coefficients; CN, clinically normal; Cogstate CBB, Cogstate Brief Battery; Cogstate CPAL, Cogstate Continuous Paired Associate Learning; d, Cohen's d; NIHTB‐CB, National Institutes of Health Toolbox Cognition Battery; CANTAB, Cambridge Neuropsychological Test Automated Battery; PACC, Preclinical Alzheimer Cognitive Composite; PiB, Pittsburgh compound B positron emission tomography; ρ r, Spearman correlation; r, correlation coefficient.

Note: Only published articles are included in this table.