Figure 1.

Long non-coding RNAs (lncRNAs) regulate immune escape in the tumor immune microenvironment (TIME). At the microenvironmental level, lncRNAs are involved in mediating and controlling various immune and cancer cell interactions, promoting the activation of immunosuppressive cells and factors [e.g., myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophage (TAMs) subsets]. Abnormal antitumor immune cells [e.g., dendritic cell (DC), natural killer (NK) cells, and T cells] and regulatory cells T cells (Tregs) induce the formation of an immunosuppressive microenvironment, thus contributing to the immune escape of tumor cells.