. Author manuscript; available in PMC: 2022 Mar 15.

Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Oct 24;109(4):1054–1075. doi: 10.1016/j.ijrobp.2020.10.021

Table 2:

Summary of currently available deformable image registration and relevant adaptive radiation therapy components

Vendor	DIR Algorithm	Unimodal Registration (CT, CBCT)	Multimodal Registration (CT, PET, MR)	Contour Propagation	Dose Warping and Summation	Offline ART	Online ART
Stand-alone deformable image registration products
MIM (v6.8)	Free-form, Demons optical flow^{27, 28}	YES	YES	YES	YES	NO	NO
Velocity (v3.2)	Multipass B-spline²⁹	YES	YES	YES	YES	YES^*	NO
Mirada (vRTX1.8)	Unimodal: free-form Multimodal: Radial basis function³⁰	YES	YES	YES	YES	YES^*	NO
Treatment planning systems with deformable image registration modules
Raystation (v9A)	ANACONDA³¹, MORFEUS³²	YES	YES	YES	YES	YES	NO
Eclipse (v15.6)	Unimodal: Accelerated Demons³³ Multimodal: Adaptive gridbased Radial basis function	YES	YES	YES	YES	YES	NO
Pinnacle (v9.10)	Fast symmetric Demons, Salient-Feature-Based Registration (SFBR)^{34, 35}	YES	YES	YES	YES	NO	NO
Monaco (v5.51)	Gradient-free Dense Hybrid MI Deformation^{36, 37}	YES	YES	YES	YES	YES	YES
Precision (v2.1)	Multi-organ B-Spline³⁸	YES	YES	YES	YES	YES	YES
ViewRay (v5.2.5)	Free-form Unimodal: Correlation coefficient Multimodal: Mutual Information	YES	YES	YES	NO	YES	YES

ANACONDA= ANAtomically CONstrained Deformation Algorithm; MORFEUS= Multi-organ Finite Element Modeling Algorithm

Partial offline ART functionality (no treatment planning)