Table 2.

Cox proportional hazard model for estimation of adjusted HRs on coronary artery disease.

	No. of CAD	Observed Person-Years	Incidence Density (Per 1,000 Person-Years)	Crude HR	95% C.I.	p-value	Adjusted HR†	95% C.I.	p-value
Endometriosis
No	159	122,678	1.3	1			1
Yes	199	108,346	1.8	1.46	1.19–1.80	<0.001	1.52	1.23–1.87	<0.001
Age
20–39	98	136,674	0.7	1			1
40–49	209	83,225	2.5	3.60	2.83–4.58	<0.001	2.51	1.94–3.24	<0.001
50–54	36	9,095	4.0	5.97	4.07–8.76	<0.001	2.36	1.55–3.58	<0.001
≥55	15	2,031	7.4	11.00	6.39–18.95	<0.001	3.14	1.74–5.66	<0.001
Hypertension	53	6,210	8.5	6.66	4.97–8.92	<0.001	1.90	1.37–2.65	<0.001
Hyperlipidemia	14	2,467	5.7	4.05	2.37–6.92	<0.001	1.12	0.63–2.00	0.695
Diabetes	29	2,740	10.6	7.76	5.3–11.34	<0.001	2.58	1.68–3.97	<0.001
Cancer	6	3,194	1.9	1.28	0.57–2.87	0.548	0.96	0.42–2.17	0.915
COPD	3	1,204	2.5	1.59	0.51–4.95	0.425	1.52	0.48–4.77	0.476
Autoimmune disease	4	1,039	3.8	2.60	0.97–6.97	0.057	2.04	0.76–5.49	0.160
Hysterectomy/oophorectomy	89	22,713	3.9	3.09	2.43–3.92	<0.001	1.42	1.10–1.84	0.007
Stroke	58	7,344	7.9	5.70	4.30–7.55	<0.001	2.11	1.56–2.86	<0.001
Outpatient visits	–	–	–	0.999	0.998–0.9998	0.014	0.996	0.995–0.997	<0.001
Corticosteroids	209	154,386	1.4	0.64	0.52–0.79	<0.001	0.67	0.54–0.84	<0.001
NSAIDs	354	228,782	1.5	0.74	0.28–2.00	0.557	1.01	0.37–2.75	0.983
Aspirin	215	30,318	7.1	9.55	7.73–11.81	<0.001	9.44	7.45–11.96	<0.001
Statin	112	26,296	4.3	3.40	2.72–4.26	<0.001	1.35	1.04–1.75	0.023

^†Adjusted for age, hypertension, hyperlipidemia, diabetes, cancer, COPD, autoimmune disease, hysterectomy/oophorectomy, stroke, outpatient visits, corticosteroids, NSAIDs, aspirin, and statin.

COPD, Chronic obstructive pulmonary disease.

NSAIDs, Non-Steroidal Anti-Inflammatory Drugs.