Table 3.
Subgroup analysis of Cox proportional hazard model.
| Endometriosis | Non-endometriosis | ||||||
|---|---|---|---|---|---|---|---|
| N | No. of CAD | N | No. of CAD | HR | 95% CI | p-value | |
| Age | |||||||
| 20–39 | 7,970 | 58 | 7,967 | 40 | 1.73 | 1.16–2.59 | 0.008 |
| 40–49 | 5,229 | 112 | 5,216 | 97 | 1.33 | 1.02–1.75 | 0.039 |
| 50–54 | 640 | 20 | 657 | 16 | 1.50 | 0.78–2.90 | 0.228 |
| ≥55 | 149 | 9 | 148 | 6 | 1.67 | 0.59–4.68 | 0.333 |
| p for interaction = 0.785 | |||||||
| Hypertension | |||||||
| No | 13,536 | 171 | 13,534 | 134 | 1.50 | 1.20–1.88 | <0.001 |
| Yes | 452 | 28 | 454 | 25 | 1.27 | 0.74–2.17 | 0.392 |
| p for interaction = 0.592 | |||||||
| Hyperlipidemia | |||||||
| No | 13,802 | 191 | 13,799 | 153 | 1.46 | 1.18–1.81 | <0.001 |
| Yes | 186 | 8 | 189 | 6 | 1.55 | 0.54–4.47 | 0.418 |
| p for interaction = 0.859 | |||||||
| Diabetes | |||||||
| No | 13,779 | 184 | 13,802 | 145 | 1.49 | 1.20–1.85 | <0.001 |
| Yes | 209 | 15 | 186 | 14 | 1.06 | 0.51–2.20 | 0.875 |
| p for interaction = 0.376 | |||||||
| Cancer | |||||||
| No | 13,760 | 196 | 13,745 | 156 | 1.47 | 1.19–1.82 | <0.001 |
| Yes | 228 | 3 | 243 | 3 | 1.01 | 0.20–5.02 | 0.987 |
| p for interaction = 0.672 | |||||||
| COPD | |||||||
| No | 13,917 | 197 | 13,922 | 158 | 1.46 | 1.19–1.80 | <0.001 |
| Yes | 71 | 2 | 66 | 1 | 1.90 | 0.17–20.94 | 0.601 |
| p for interaction = 0.785 | |||||||
| Autoimmune disease | |||||||
| No | 13,914 | 196 | 13,918 | 158 | 1.45 | 1.18–1.79 | 0.001 |
| Yes | 74 | 3 | 70 | 1 | 3.88 | 0.40–37.77 | 0.243 |
| p for interaction = 0.442 | |||||||
| Hysterectomy/oophorectomy | |||||||
| No | 12,525 | 152 | 12,535 | 117 | 1.56 | 1.23–1.99 | <0.001 |
| Yes | 1,463 | 47 | 1,453 | 42 | 1.10 | 0.73–1.67 | 0.644 |
| p for interaction = 0.161 | |||||||
| Stroke | |||||||
| No | 13,594 | 170 | 13,591 | 130 | 1.53 | 1.22–1.92 | <0.001 |
| Yes | 394 | 29 | 397 | 29 | 1.16 | 0.69–1.94 | 0.574 |
| p for interaction = 0.330 | |||||||
| Corticosteroids | |||||||
| No | 5,575 | 87 | 5,558 | 62 | 1.70 | 1.22–2.35 | 0.001 |
| Yes | 8,413 | 112 | 8,430 | 97 | 1.34 | 1.02–1.76 | 0.036 |
| p for interaction = 0.199 | |||||||
| NSAIDs | |||||||
| No | 247 | 2 | 254 | 2 | 1.04 | 0.15–7.41 | 0.965 |
| Yes | 13,741 | 197 | 13,734 | 157 | 1.47 | 1.19–1.81 | <0.001 |
| p for interaction = 0.819 | |||||||
| Aspirin | |||||||
| No | 12,438 | 87 | 12,431 | 56 | 1.79 | 1.28–2.50 | 0.001 |
| Yes | 1,550 | 112 | 1,557 | 103 | 1.23 | 0.94–1.60 | 0.137 |
| p for interaction = 0.068 | |||||||
| Statin | |||||||
| No | 12,621 | 138 | 12,592 | 108 | 1.48 | 1.15–1.90 | 0.002 |
| Yes | 1,367 | 61 | 1,396 | 51 | 1.37 | 0.94–1.98 | 0.100 |
| p for interaction = 0.634 | |||||||
Hazard ration (HR) was estimated by univariate Cox proportional hazard model.
COPD, Chronic obstructive pulmonary disease.
NSAIDs, Non-Steroidal Anti-Inflammatory Drugs.