TABLE 3.
Major Nonrespiratory Morbidities Among Survivors to Discharge
| Outcome | All Infants (N = 22 131) | No BPD (n = 12 192) | Grade 1–2 BPD (n = 9126) | Grade 3 BPD (n = 813) |
|---|---|---|---|---|
| Early onset bacterial sepsis or meningitisa | 279 (1.3) | 134 (1.1) | 125 (1.4) | 20 (2.5) |
| Late onset bacterial or fungal sepsis or meningitisa | 2209 (10.0) | 582 (4.8) | 1372 (15.0) | 255 (31.4) |
| Severe brain injury on cranial imagingb | 1934 (8.9) | 569 (4.8) | 1177 (13.1) | 188 (23.4) |
| Surgical or interventional closure of a PDA | 1122 (5.1) | 96 (0.8) | 859 (9.4) | 167 (20.6) |
| Surgery for confirmed or suspected NEC or bowel perforation | 786 (3.6) | 175 (1.4) | 472 (5.2) | 139 (17.1) |
| Surgery or anti-VEGF therapy for ROP | 1210 (5.5) | 141 (1.2) | 882 (9.7) | 187 (23.0) |
Data shown in the table are number of infants (%). All percentage values were calculated among infants with complete data for the described variable. Data shown in the table were missing in <1% of study infants, except for severe brain injury on cranial imaging, which was missing for 2.1% of the cohort. NEC, necrotizing enterocolitis; PDA, patent ductus arteriosus; VEGF, vascular endothelial growth factor.
Early onset infection occurred on or before day 3 after birth; late onset infection occurred after day 3. All infections were identified by using a culture of blood or cerebral spinal fluid.
Defined as a grade 3 or 4 intraventricular or periventricular hemorrhage and/or cystic periventricular leukomalacia.