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. 2021 Jun 9;1(2):74–85. doi: 10.1097/ID9.0000000000000010

Figure 4.

Figure 4

Integration of metabolomics data and KEGG reaction information in an undirected network. Node shape indicates biochemical functions of the metabolite. Edges were generated based on KEGG RPAIR substrate-product reaction database. (A) Differential metabolites (FDR < 0.05) from the comparison of healthy controls and patients are mapped to the network. Node size indicates the absolute log fold change of the metabolites. (B) to (D) Differential metabolites (P < 0.05) from the comparison of mild and moderate patients, mild and severe, moderate and severe are mapped to the network, respectively.